Monthly Archives: December 2022

Avatar no hace justicia al mundo de Avatar

Después de trece años es normal y esperable que Avatar 2 decepcione y que la primera no haya sobrevivido al paso del tiempo. Hasta la gente más fanboy de Avatar, como lo fui yo, ha acabado pensando lo mismo. Yo no vengo a hablar de esto, porque mil gentes han venido antes de mí para explicarlo mil veces mejor. (Empezando por Hello Future Me, Amanda the Jedi, o Sideways). Yo vengo a hacer el apunte de que lo más interesante de Avatar nunca fue la historia, si no el mundo, pero es una pena que en las pelis no se entre al detalle que merece.

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paper newsletter #02

A bit late this week, since we’re reaching the holidays, but here we are anyway. Remember I mostly skim through these, I take these briefings as a way to engage in the content, and that most of my sources come from Twitter and Mastodon:

  • Things could be better: A very interesting read, all the more because the way it is written, on why the human mind tend to imagine how things could be better when prompted to imagine how things could be different. As in, we immediately jump to think about the better version of something, and not the worse version of something, when asked how a given thing could be different –no matter the wording of this question, the language it is asked in, etc . Are we poised for expecting or demanding improvement? I also find it amazingly well written and accessible. Papers should read like this.
  • Moonlight2 for identifying driver genes: originally thought for cancer research, a nice mix of GRN inference and data mining to identify marker and driver genes. Could it be adapted for other types of data if provided with a different type of annotation –not cancer data and literature, but e.g. a given biological process of interest?
  • scTensor detects many-to-many cell–cell interactions from single cell RNA-sequencing data: a tool that relies on ligand-receptor annotation and gene co-expression to infer interactions between cells. Especially interesting when describing de novo datasets.

More later this week!

paper newsletter #01

I’ve been meaning to do a newsletter to keep my readings/tabs organised for a while but I am terrible at getting things started. This is part of a motivation influx I had two months ago after a couple of congresses (the other part being having learned to code in functions and using markdowns) and after being subscribed to learnbyexample’s newsletter for almost a year now. I’ll do my best to explain in simple lay words the concept behind the papers/resources, most times having read only the abstract or skimmed through very quickly.

Let’s get started:

  • Unclearing microscopy : a novel method to visualise cells without the need of a microscope, by “revealing” the cell membranes using a chemical reaction that is expanded volumetrically while keeping the original cell shape.
  • Predicting evolution: a review on the major advances in evolutionary biology and population genetics, and how we can infer patterns on clonal competition across all biological systems studied. This hints at potential predictions of the principles of a modern evolutionary theory.
  • Anticor_features: finding anticorrelation patterns in single cell data that can help identify divergent cell types. Also a way of performing negative controls in these studies to prevent excessive sub-clustering. A twitter thread here.

More soon!

Sobre la envidia

Escuchado en el podcast de Ángel Martín con Angy. Quien me hubiera dicho a mí de adolescente que estos dos acabarían hablando y que darían tremendo insight vital:

“La envidia tiene un componente de yo quiero ser tú, pero [si ese] querer estar en su lugar tiene el más mínimo porcentaje de “ojalá no te hubiera pasado eso a ti”, si tiene lo más mínimo de eso, [entonces no se está entendiendo bien.]”

“Yo creo que todo lo que no sea celebrar el hecho de saber que eso que ha conseguido esa persona significa que se puede conseguir, significa que no se están entendiendo las reglas del juego. No entiendo que no seamos capaces de coger a cualquiera que consiga algo que a nosotros nos gustaría como ejemplo de por dónde hay que ir.”

Se dijeron muchas más cosas interesantísimas ese día y otros muchos días con mucha otra gente. Yo acabo de descubrir que esto existe y me lo estoy pimplando como el que se pone a comer pipas. Debería retomar terapia? Sí. Que este podcast es más barato y me tiene al tanto pensando de todos estos temas? También.